Fig. 1

Targets selected for imaging within human epidermis, in the context of ERK-MAPK signalling. A Systems Biology Graphical Notation activity flow diagram [15] of ERK-MAPK and some regulatory relationships that motivated the selection of other targets for this work. Detailed information on these targets (HUGO Gene Nomenclature Committee symbol, UniProt identifiers, etc.) is given in Table AF3.1 in Additional file 3, and references for the relationships between the different proteins (activity flow) are given in Table AF3.2 in Additional file 3. Cyto, cytoplasm; Nuc, nucleus; Memb, plasma-membrane; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, MAPK/ERK kinase