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Fig. 2 | GigaScience

Fig. 2

From: The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate

Fig. 2

Fast-evolving and positively selected genes in the GH/IGF1 axis. a Schematic representation of GH/IGF-1 signalling, adapted from [80]. Arrows denote the direction of signal transduction, whereas the grey ellipse represents an enzyme or a cytokine. Purple stars indicate genes exhibiting elevated dN/dS (fast evolution), whereas the yellow stars indicate positive selection. b 3D structure of IGF1Ra and (c) IGF1Rb monomers as predicted by the SWISS-MODEL Workspace [81]. The bar above the 3D structure indicates the structural domains. Red lines in the bar and the red atom balls in the 3D structure represent the positively selected sites. Domains in the 3D structure are coloured according to the colour scheme on the bar. The pink-surface model in the centre of the IGF1R structure is IGF-1. Akt, protein kinase B; CR, furin-like cysteine rich region (PF00757); FnIII, fibronectin type III domain (PF00041); GH, growth hormone; GHR, growth hormone receptor; GRB2, Growth factor receptor-bound protein 2; IGF-1, Insulin-like growth factor 1; IGF1R, Insulin-like growth factor 1 receptor; INSR, Insulin receptor; IRS, Insulin receptor substrate; JAK2, Janus kinase 2; MAPK, Mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; RL, receptor L domain (PF01030); SHC1, SHC-transforming protein 1; STAT5, signal transducer and activator of transcription 5

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