OPTIMA: sensitive and accurate whole-genome alignment of error-prone genomic maps by combinatorial indexing and technology-agnostic statistical analysis

Table 5 Comparison of methods for overlap map-to-sequence alignment

Algorithm	Drosophila (A)		Drosophila (B)		Human (A)		Human (B)		Human real data
	E	P	E	P	E	P	E	P	E
OPTIMA-overlap	91	100	53	98	72	99	29	97	23
Gentig v.2 (d)	69	100	29	93	51	93	19	83	14
Likelihood-overlap (d + a)	59	74	36	52	21	41	9	26	12

The precision of overlap alignments (P, in percentages) and the number of overlap alignments that lead to (correct) extensions (E, absolute values) as a measure of sensitivity (correctness is only known for simulated datasets) are shown. The best values across methods are highlighted in bold

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