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Table 5 Examples of predictions by CONS and individual-component methods. Succinate dehydrogenase iron-sulfur subunit (UniProt ID: P51053)

From: The PFP and ESG protein function prediction methods in 2014: effect of database updates and ensemble approaches

Method

GO id

Confidence score

GO term

CONS

GO:0051536

1.00

iron-sulfur cluster binding

 

GO:0009055

0.25

electron carrier activity

 

GO:0051539

0.24

4 iron, 4 sulfur cluster binding

 

GO:0046872

0.24

metal ion binding

 

GO:0006099

0.22

tricarboxylic acid cycle

 

(GO:0016020)

0.21

 
 

GO:0051537

0.21

2 iron, 2 sulfur cluster binding

 

GO:0051538

0.21

3 iron, 4 sulfur cluster binding

 

GO:0016491

0.16

oxidoreductase activity

 

GO:0055114

0.16

oxidation-reduction process

 

GO:0009060

0.16

aerobic respiration

 

GO:0022900

0.14

electron transport chain

 

(GO:0008177)

0.13

 
 

…and 9 more terms

 
 

GO:0000104

0.10

succinate dehydrogenase activity

PFP

GO:0055114

1.00

oxidation-reduction process

 

GO:0051540

1.00

metal cluster binding

 

…and 10 more terms

 
 

GO:0051539

0.52

4 iron, 4 sulfur cluster binding

 

GO:0009055

0.46

electron carrier activity

 

(GO:0005886)

0.46

 
 

(GO:0071944)

0.44

 
 

(GO:0044435)

0.43

 
 

GO:0022900

0.42

electron transport chain

 

…and 9 more terms

 
 

GO:0046872

0.35

metal ion binding

 

…and 6 more terms

 
 

GO:0006099

0.33

tricarboxylic acid cycle

 

…and 8 more terms

 
 

GO:0000104

0.25

succinate dehydrogenase activity

 

(GO:0050136)

0.23

 
 

(GO:0003954)

0.23

 
 

GO:0051537

0.22

2 iron, 2 sulfur cluster binding

 

GO:0051538

0.20

3 iron, 4 sulfur cluster binding

ESG

(GO:0005743)

0.66

 
 

GO:0006099

0.66

tricarboxylic acid cycle

 

(GO:0008177)

0.66

 
 

GO:0009055

0.66

electron carrier activity

 

GO:0046872

0.66

metal ion binding

 

GO:0051537

0.66

2 iron, 2 sulfur cluster binding

 

GO:0051538

0.66

3 iron, 4 sulfur cluster binding

 

GO:0051539

0.66

4 iron, 4 sulfur cluster binding

 

(GO:0005749)

0.60

 
 

(GO:0048039)

0.60

 
 

GO:0022900

0.56

electron transport chain

 

(GO:0016020)

0.80

 
 

GO:0051538

0.80

3 iron, 4 sulfur cluster binding

 

GO:0051539

0.80

4 iron, 4 sulfur cluster binding

 

GO:0051536

0.80

iron-sulfur cluster binding

 

(GO:0006810)

0.80

 
 

(GO:0009061)

0.80

 
 

GO:0046872

0.80

metal ion binding

 

GO:0006099

0.80

tricarboxylic acid cycle

 

GO:0009060

0.80

aerobic respiration

 

(GO:0005489)

0.80

 
 

GO:0051537

0.80

2 iron, 2 sulfur cluster binding

 

(GO:0005506)

0.80

 
 

GO:0000104

0.80

succinate dehydrogenase activity

 

(GO:0006118)

0.80

 
 

GO:0016491

0.80

oxidoreductase activity

  1. GO terms in bold are correct annotations of the protein. Terms in italic indicate parental terms of correct GO terms. Terms in parentheses are wrong predictions
  2. For CONS, PFP, and ESG prediction, GO terms that have a confidence score equal to or larger than 0.10, 0.20, and 0.56, respectively, are shown (i.e. up to the last correct GO term). For PSI-BLAST all predicted GO terms are shown
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