Fig. 3
From: SMAP: a streamlined methylation analysis pipeline for bisulfite sequencing
ASM detection. Purple Cs are methylated, whereas red Ts are not methylated. Me: Methylated site. a Basic case in which two C bases are methylated. b An example of an ASM region in a monoclonal tumor marked by a heterozygous G/T SNP. c An example of a polyclonal tumor in which the heterozygous SNP and reference allele are present. d An example of another type of polyclonal tumor in which the heterozygous SNP was changed to a homozygous G allele due to loss of heterozygosity