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Table 3 Comparison of consensus genotypes and SNVs detection accuracy of deep-sequenced data amplified by MDA and MALBAC

From: Comparison of variations detection between whole-genome amplification methods used in single-cell resequencing

Control/sample

Heterozygous (FP/ADO/Efficiency)

Homozygous (FP/Efficiency)

Total (FP/Efficiency)

FP ratio

ADO Ratio

YH-mix (Unamplified control)

2051,282

1,598,291

3,649,573

-

-

MDA-2_46

777,908 (5563/390,038/37 %)

1,747,004 (390,107/84 %)

2,524,912 (395,670/58 %)

1.32E-04

0.3340

MDA-2_47

1,807,282 (6517/14,124/87 %)

1,562,036 (14,177/96 %)

3,369,318 (20,694/91 %)

6.90E-06

0.0078

MDA-2_66

1,651,733 (6347/55,158/80 %)

1,587,456 (55,195/95 %)

3,239,189 (61,542/87 %)

2.05E-05

0.0323

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