Fig. 4

Read-data CNVs detection comparison between MALBAC and MDA-2 amplified data. a Taking the simulated YH-mix data as control, sensitivity and specificity of CNVs (≥1 Mb) in simulated single YH cells amplified by different WGA methods are bar-plotted. b CNVs of BGC823 single cells amplified by MALBAC or MDA-2. BGC823 single cells are sequenced on the Ion Proton sequencer (~0.5X) as control. Bulk BGC823 sequencing data (bottom row) are sequenced by PE-100 on an Illumina Hiseq 2000 (~50X), and ~1X data was extracted randomly to detect CNVs. Green, red, and blue represent normal, amplification, and deletion, respectively