Fig. 2

LWGS Comparison of recovery sensitivity and amplification uniformity between WGA methods. a The recovery sensitivity comparison of three different WGA methods using 0.1X randomly extracted LWGS data. The histogram and line graph show the mean mapping ratio and mean duplication ratio of different methods, respectively. b The mean normalized depth distribution of the seven WGA kits using the 0.1X sequencing data. The normalized read depth is defined as the ratio of the mean depth of all reads in each window to the mean depth of the whole genome. The binning window is 100 kb. The dashed curve is plotted using the simulated data (1000 dots) that followed the Poisson distribution (λ = 30) and normalized by dividing by 30. c A comparison of mean normalized depth distribution in chr15:q11.1-q26.3 between different WGA kits. The binning window is 100 kb. YH-mix is used as the unamplified control