Figure 4

Post-processing of automatic annotations. UniProt have rules in place such that if the taxon restrictions are violated in automatic annotations, the annotation can be either deleted (row 1) or edited to use a more appropriate GO term (row 2). In row 1, an Entamoeba protein is annotated to “peroxisome”, these organelles are only present in cellular organisms therefore the annotation is deleted. In row 2, a viral protein is annotated to “cytoplasm”, for viruses the correct GO term to use is “host cell cytoplasm” therefore the GO term is substituted and a GO reference describing this editing process is supplied with the annotation.