Figure 3

Inheritance of taxon restrictions. Less specific, parent terms have fewer taxon restrictions than more specific child terms that are further down the hierarchy. This should be considered when choosing GO terms to use in automatic prediction methods. In the example shown, predicting the term “fatty acid beta-oxidation multienzyme complex” for a set of multispecies proteins may result in more accurate annotation than predicting the term “mitochondrial fatty acid beta-oxidation multienzyme complex”.