Insensitivity of the selection phase boundary to the distribution of coefficient magnitudes (ensemble). (A)
s = 125 coefficient magnitudes (“effect sizes”) ordered from large to small for the Uniform (blue), Hyperexponential 1 (red), and Hyperexponential 2 (green) ensembles. (B) Chromosome 22 analysis using μ
P − value to measure selection (normalized by the maximum value) as a function of sample size for h
2 = 1 for the Uniform (blue) and Hyperexponential 1 (red) ensembles. (C) As in panel (B) except for h
2 = 0.5. Also shown is recovery for the Hyperexponential 2 ensemble (green).