Map of SNPs associated with height, as identified by the GIANT Consortium meta-analysis,
-penalized regression, and standard GWAS. Base-pair distance is given by angle, and chromosome endpoints are demarcated by dotted lines. Starting from 3 o’clock and going counterclockwise, the map sweeps through the chromosomes in numerical order. As a scale reference, the first sector represents chromosome 1 and is ∼ 250 million base-pairs. The blue segments correspond to a 1 Mb window surrounding the height-associated SNPs discovered by GIANT. Note that some of these may overlap. The yellow segments represent L
1 -selected SNPs that fell within 500 kb of a (blue) GIANT-identified nonzero; these met our criterion for being declared true positives. The red segments represent L
1 -selected SNPs that did not fall within 500 kb of a GIANT-identified nonzero. Note that some yellow and red segments overlap given this figure’s resolution. There are in total 20 yellow/red segments, representing L
1 -selected SNPs found using all 12,454 subjects. The white dots represent the locations of SNPs selected by MR at a P -value threshold of 10− 8.