Figure 3

Two KEGG pathways from the aye-aye data. A) KEGG pathway diagram showing the genes with coding mutations involved in the extracellular matrix-receptor interaction pathway. Eleven genes with SNPs in the top 5% by LSBL score in the West aye-aye population appear in this pathway, including three with non-synonymous mutations (LAMC2, HSPG2, and LAMA3). These genes are grouped in 5 different functional units distributed along the pathway (i.e., collagen, laminin, tenascin, perlecan, and SV2, all shown in red). B) KEGG pathway diagram for the Glycosylphosphatidylinositol-anchor biosynthesis pathway showing the central role of the PIG-N gene for GPI-anchor synthesis.