Table 5 GWAS genes in the top 50 high-impact interactions
Publication information | Information about genes involved in the PPI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Rank | PMID | Cite count | Pub year | Symbol 1 | Symbol 2 | Name 1 | Name 2 | GWAS diseases/traits of 1 | GWAS diseases/traits of 2 |
1 | 12802337 | 160 | 2003 | ADIPOQ | ADIPOR2 | adiponectin, C1Q and collagen domain containing | adiponectin receptor 2 | adiponectin levels | |
2 | 8392057 | 8 | 1993 | NMB | NMBR | neuromedin B | neuromedin B receptor | Retinal vascular caliber | |
3 | 16600873 | 37 | 2006 | NUP93 | TMEM48 | nucleoporin 93 kDa | transmembrane protein 48 | HDL cholesterol | |
4 | 12364586 | 72 | 2002 | DAO | DAOA | D-amino-acid oxidase | D-amino acid oxidase activator | Bipolar disorder and schizophrenia | |
8 | 8702721 | 21 | 1996 | SRC | YWHAG | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | Multiple sclerosis | |
12 | 2996780 | 64 | 1985 | PRKCA | SRC | protein kinase C, alpha | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Ventricular conduction,Height | |
14 | 10766163 | 6 | 2000 | ESR1 | TP53 | estrogen receptor 1 | tumor protein p53 | Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer | |
15 | 15173068 | 8 | 2004 | ESR1 | GRB2 | estrogen receptor 1 | growth factor receptor-bound protein 2 | Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer | |
16 | 9568714 | 278 | 1998 | GATA4 | NFATC4 | GATA binding protein 4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | Retinal vascular caliber | Height |
17 | 10433554 | 4 | 1999 | PRKCA | YWHAG | protein kinase C, alpha | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | Ventricular conduction,Height | Multiple sclerosis |
18 | 8266076 | 105 | 1993 | IL2RG | IL4R | interleukin 2 receptor, gamma | interleukin 4 receptor | IgE levels | |
22 | 12732139 | 46 | 2003 | SMAD3 | TP53 | SMAD family member 3 | tumor protein p53 | Coronary heart disease,Asthma,Crohn's disease | |
23 | 1454855 | 45 | 1992 | PRKCA | TP53 | protein kinase C, alpha | tumor protein p53 | Ventricular conduction,Height | |
24 | 8266077 | 115 | 1993 | IL2RG | IL7R | interleukin 2 receptor, gamma | interleukin 7 receptor | Type 1 diabetes,Ulcerative colitis,Multiple sclerosis,Primary biliary cirrhosis | |
28 | 15324660 | 72 | 2004 | TP53 | YWHAG | tumor protein p53 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | Multiple sclerosis | |
31 | 15140878 | 17 | 2004 | ESR1 | SRC | estrogen receptor 1 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer | |
34 | 12878187 | 1 | 2003 | EGFR | PRKCA | epidermal growth factor receptor | protein kinase C, alpha | Glioma | Ventricular conduction,Height |
36 | 16192271 | 88 | 2005 | ABCA1 | DLG3 | ATP-binding cassette, sub-family A (ABC1), member 1 | discs, large homolog 3 (Drosophila) | MRI atrophy measures,HDL cholesterol,Lipid metabolism phenotypes,Cholesterol,total,Coronary heart disease | |
38 | 17057718 | 66 | 2006 | GATA3 | SATB1 | GATA binding protein 3 | SATB homeobox 1 | Hodgkin's lymphoma | Platelet counts |
39 | 15466214 | 27 | 2004 | AR | SRC | androgen receptor | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Prostate cancer,Male-pattern baldness,LDL cholesterol | |
44 | 8994038 | 82 | 1997 | GRB2 | MAPK1 | growth factor receptor-bound protein 2 | mitogen-activated protein kinase 1 | Multiple sclerosis | |
46 | 11782371 | 15 | 2002 | EP300 | ESR1 | E1A binding protein p300 | estrogen receptor 1 | Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer | |
47 | 12200137 | 1 | 2002 | IL2RG | SHB | interleukin 2 receptor, gamma | Src homology 2 domain containing adaptor protein B | Brain structure | |
50 | 7477400 | 72 | 1995 | HLA-DRB3 | POMC | major histocompatibility complex, class II, DR beta 3 | proopiomelanocortin | Type 1 diabetes,Height,Body mass index | |