Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer

Table 1 Summary of somatic mutations called in single-cell exome sequencing

Mutant alleles observed in matched tissue sequencing	Total N (%)	CDS			3′UTR N (%)	5′UTR N (%)	Intron N (%)	Intergenic N (%)
		NS N (%)	S N (%)	NS/S
Yes	374(84.42)	133(91.10)	54(91.53)	2.46	13(92.86)	7(87.50)	161(77.40)	6(75.00)
No	69(15.58)	13(8.90)	5(8.47)	2.60	1(7.14)	1(12.50)	47(22.60)	2(25.00)
Total	443(100)	146(100)	59(100)	2.47	14(100)	8(100)	208(100)	8(100)

Note: ‘NS/S’ indicated the rate of the nonsynonymous mutation count to the synonymous one in CDS region.
CDS, Coding sequence; NS, Nonsynonymous; S, Synonymous; UTR, Untranslated region.

ISSN: 2047-217X